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Home - Products - Membrane Transporter/Ion Channel - GAT - AZD 3043

AZD 3043

CAS No. 579494-66-9

AZD 3043( THRX-918661 )

Catalog No. M15126 CAS No. 579494-66-9

AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    AZD 3043
  • Note
    Research use only, not for human use.
  • Brief Description
    AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM.
  • Description
    AZD 3043 (THRX-918661) is a positive allosteric modulator of the GABAA receptor in vitro and a sedative/hypnotic agent in vivo, potentiates GABAA receptor-mediated chloride currents with EC50 of 36 uM; potentiates and directly activates the α1β2γ2, α2β2γ2 and α2β3γ2 GABA(A) receptor subtypes, produces hypnosis and electroencephalograph depression in rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    THRX-918661
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GAT
  • Recptor
    GAT
  • Research Area
    Neurological Disease
  • Indication
    Depression

Chemical Information

  • CAS Number
    579494-66-9
  • Formula Weight
    351.443
  • Molecular Formula
    C19H29NO5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CCCOC(=O)Cc1ccc(c(c1)OCC)OCC(=O)N(CC)CC
  • Chemical Name
    [4-[(N,N-Diethylcarbamoyl)methoxy]-3-ethoxyphenyl]acetic acid propyl ester

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Egan TD, et al. Anesthesiology. 2012 Jun;116(6):1267-77. 2. Jonsson Fagerlund M, et al. Eur J Pharmacol. 2012 Nov 5;694(1-3):13-9. 3. Bj?rnsson MA, et al. Anesth Analg. 2015 Oct;121(4):904-13.
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